Bactokil

Bactokil 250 Capsule: Each capsule contains Cephradine USP 250 mg.
Bactokil 500 Capsule: Each capsule contains Cephradine USP 500 mg.
Bactokil Powder for suspension: Each 5 ml reconstituted suspension contains Cephradine USP 125 mg.

Bactokil is used in the treatment of infections caused by sensitive organisms. Upper respiratory tract infections: Pharyngitis, sinusitis, tonsillitis. Lower respiratory tract infections: Acute & chronic bronchitis, labor & bronchopneumonia. Urinary tract infections: Cystitis, urethritis. Skin & soft tissue infections: Abscess, cellulites, impetigo. Gastrointestinal tract infections: Bacillary dysentery, enteritis. Bone & joint infection. Surgical Prophylaxis: It is also used in pre-operative prophylactic.

The dosage may be given without regard to meals. Adult: Oral: The usual dose is 1-2 gm daily in 2 to 4 divided doses. In severe & prolonged infection, the dose can be increased up to 4 gm daily which should be taken in equally divided doses. Special dose in the following infections: Skin & skin structures & respiratory tract infection: Usual dose is 250 mg every 6 hours or 500 mg every 12 hours. Lobar pneumonia: 500 mg every 6 hours or 1 gm every 12 hours. Urinary tract infection: Usual dose is 500 mg every 12 hours. Gastro-intestinal tract infection: 500 mg 3 to 4 times daily. Children: Oral: The usual dose is 25 to 50 mg/ kg/ day given in 2 to 4 equally divided doses. Dosage in renal impairment: In patients with impaired renal function, doses & frequency of administration of Cephradine must be modified according to the degree of impairment, severity of infection, susceptibility of the causative organism & serum concentration of the drug. For adults, a loading dose of 750 mg should be given subsequently followed by 500 mg with the mentioned the interval.
Creatinine clearance (ml/min) Time interval (hrs)

• Creatinine clearance (ml/min) = Time interval (hrs)
• >20 =6- 12
• 15- 19 =12- 24
• 10- 14= 24- 40
• 5- 9 =40- 50
• <5 =50- 70

For children, dosage schedule may need to be adjusted.

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